Description
Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. It’s called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants.
According to scientific studies that have been carried out on animals, PEG MGF works with a secretion known as a mechanical growth factor (hence MGF in the peptide name). This secretion is produced by counterbalancing the terminally-terminated cellular effects which results in the growth and repair of the musculoskeletal tissue. In other words, it not only plays a role in the regulation of skeletal muscle tissue, but also inhibits the last stage of cell differentiation in which cells do not work. The general disadvantage of the functionality of the mechanical growth factor is that it has a very fast half-life, only a few minutes.
However, PEG MGF is able to extend the half-life of the mechanical growth factor through a process called PEGylation. In essence, this process allows covalent linking between the peptide and the secretion. This in turn is used for fixing and as a protective barrier for the mechanical growth factor molecule. This method allows the secretion to pass through the blood without experiencing the level of degradation that occurs in other cases. This method of protection – and the prolongation of the half-life, thus enables an increase in the level of durability, which also allows general secretion functions. In this case, research has established that this increased functionality translates into increased levels of muscle growth and repair, which in turn leads to more effective means of achieving homeostasis.
Scientific research has determined that Peg MGF’s functional processes have allowed him to be the key to the lifting of several elementary processes that are associated with muscles, tissue growth and repair. Some of these methods include: better skeletal muscle regeneration, – since PEG MGF has shown an increase in the half-life of mechanical growth factor to pegylation initiation methods, studies have shown that the presence of peptide may increase the ability to build and repair muscle tissue, skeletal in a much more effective way. Improving bone density – scientific research has established that the ability of PEG MGF to promote skeletal tissue growth and repair ties is the ability to induce an increased amount of bone mineral. For this reason, it is believed that the presence of the peptide may allow the subject to experience an increase in bone density. This elevated process may lead to bones being stronger, more durable and less susceptible to breaks. Faster, more efficient ways to recover from injuries – scientific research has shown that the overall functionality of PEG MGF gives rise to impulse at a time when materials that are needed to repair muscle fibers and skeletal tissue can be used. Due to this, the functionality is increased and it was found that it causes more effective treatment.
The harder you train your muscles the more you tear the muscle fibers. This is what creates the soreness a day or two after the workout. The body naturally releases Mechano GF localized in the muscle to get to work on the damaged tissue. It is not like growth hormone mediated IGF1 production that is produced in the liver. If there is no Mechano GF the damaged muscle cells will die and you will become smaller and smaller and your muscles will waste away without this function. MGF replenishes the pool of stem cells in muscle tissue in a pulse after muscles were damaged.
What makes MGF special is its’ unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.
The liver produces 2 kinds of MGF splice variants of IGF
1) IGF-1Ec: This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.
2) Liver type IGF-IEa: this is the secondary release of igf from the liver, and its far less anabolic.
MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle; in other words, it is more anabolic and longer acting than the systematic release of the second MGF liver variant.
So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.
In rats, some studies have shown muscle mass increases of 20 percent from a single MGF injection, but somehow, many of these studies are not accurate, however the potential is undeniable.
How to use
When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.
As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.
Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained. The only problem with MGF is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged. That’s why we think the best option is PEG MGF. Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.
What is PEG MGF (pegylated mechano growth factor)?
MGF that’s pegylated, which means it has the addition of Polyethylene glycol – a non toxic additive that increased the half life of MGF from minutes to hours. This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal. I have found it most effective, as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased.
The next aspect we need to look at is how to make the most use of a long acting version of MGF.
When your muscle is damaged, your body releases a pulse of an MGF splice variant as I outlined above, followed by a less anabolic longer acting version from the liver. Therefore, it seems a waste to inject MGF at this time as you will just blunt your body’s own release, your not enhancing it. So using PEG MGF on non workout days is actually the best route. Since the muscle has been damaged, there are plenty of receptors for MGF, and the effects are systematic. All muscles will be aided in recovery through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to sky rocket. Doing this means you’re increasing the length of your body’s own mechanism for muscle repair and growth, and you’re opening up the anabolic window.
Side Effects
The only reported side effects are temporary irritation, such as redness and itching at the injection site.
Dosage
The first school of thought is to administer 200mcg to 300mcg bi-laterally directly into the muscles. Using an insulin syringe after training. Because the MGF PEG is long acting it will cause the proliferation process to be extended over many hours. The following day you can follow it up with a injection of IGF1 R3 Long (30mcg to 50mcg bilaterally). Injected into the same muscle (some guys are happy with taking the IGF1 R3 Long subcutaneous but I would put it straight to the muscle).
IGF1R3 Long stays in the system for 24 hours. It will be counterproductive to inject IGF1 to soon. Enough time must elapse for MGF proliferation to be optimal. With this method you train your lacking body part twice a week. On those days, take MGF PEG straight into the muscle directly after training. The other 5 days of the week you take 30mcg to 50mcg bilaterally IGF1 R3 Long.
The second school of thought is to extend the proliferation process over four weeks and concentrate on proliferation before introducing IGF1 R3 Long to create differentiation. With this method you increase the dose to 500mcg of MGF bilaterally twice a week 3 to 4 days apart while also training the lacking body part twice a week. You do this for four weeks without introducing any synthetic IGF1 R3 Long. After four weeks you take IGF1 R3 Long 25mcg to 50mcg bilaterally in any muscles of your choice or as a single injection of 50mcg to 100mcg subcutaneous (remember its active for 24 hours so it would benefit the entire body and all the muscles)
Administration
These are the two ways of administering MGF. Doing the injection is also very interesting and there are two ways of doing it. Some guys who do small muscles like a tricep head, bicep head or rear deltoid will take one or two injections with a small insulin syringe of 30 gauge straight into the muscle. In other words, if you take 500mcg per side you will split it into two 250mcg injections into the bicep. When however you are doing a flat and wide muscle like chest the guys will go as far as splitting the 500mcg dose into ten x small 50mcg injections and spread it over the entire area of the chest on both sides to create equal proliferation of stem cells. You must also experiment with to find the optimal way.